Journal: Materials Today Bio
Article Title: Macrophage targeted cellular microparticles synergize anti-tuberculosis therapy combining CircRNA-mediated host immune defense and antibiotic killing
doi: 10.1016/j.mtbio.2025.102489
Figure Lengend Snippet: Gal-CircRNA@Rif@MPs promote autophagy of host cells in the lung of H37Ra infected mice. (A) Fluorescence imaging of DAPI, LC3B and LAMP1 staining in the lung of mice in different groups at the endpoint of experiment, scale bar: 25 μm. (B) Statistical analysis of the relative fluorescence intensity of LC3B in the lung of mice in different groups at the endpoint of experiment, n = 8, ***p < 0.001. (C) Statistical analysis of the relative fluorescence intensity of LAMP-1 in the lung of mice in different groups at the endpoint of experiment. n = 8, ***p < 0.001. (D) Typical TEM images for the lung tissues of mice with or without Gal-CircRNA@Rif@MPs treatment, scale bar: 1 μm.
Article Snippet: Fluorescence staining of DAPI, LC3B (Cell Signaling 43566, USA) and LAMP1 (Cell Signaling 73294, USA) was used to determine autophagy in lung tissues.
Techniques: Infection, Fluorescence, Imaging, Staining